Maddrey Discriminant Function Calculator

Maddrey Discriminant Function (mDF) for severity and prognosis of alcoholic hepatitis.

For educational and clinical reference. Not a substitute for medical judgment. See the medical disclaimer.
Discriminant Function
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Interpretation
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References

  1. Maddrey WC, Boitnott JK, Bedine MS, et al. Corticosteroid therapy of alcoholic hepatitis. Gastroenterology. 1978;75(2):193-199.

How to use

  1. Enter the patient prothrombin time, the laboratory control PT, and total bilirubin.
  2. The discriminant function and severity interpretation update instantly.
  3. A value ≥ 32 indicates severe disease — consider corticosteroids.

Frequently asked questions

What is the Maddrey Discriminant Function?

The mDF estimates short-term prognosis in alcohol-associated hepatitis using prothrombin time and total bilirubin.

What mDF value is severe?

A discriminant function ≥ 32 defines severe alcoholic hepatitis with high 28-day mortality, the threshold for considering corticosteroids.

What prothrombin times should I enter?

Use the patient’s PT and the laboratory’s control (reference) PT in seconds — the difference drives the score.

How does mDF guide treatment?

mDF ≥ 32 (often with hepatic encephalopathy) supports corticosteroid therapy after excluding contraindications; the Lille model at day 7 then assesses response.

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