FIB-4 Index Calculator

FIB-4 index for non-invasive estimation of advanced liver fibrosis.

For educational and clinical reference. Not a substitute for medical judgment. See the medical disclaimer.
FIB-4 Index
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Interpretation
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References

  1. Sterling RK, Lissen E, Clumeck N, et al. Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection. Hepatology. 2006;43(6):1317-1325.

How to use

  1. Enter age, AST, ALT, and platelet count.
  2. The FIB-4 index and fibrosis risk band update instantly.
  3. Use age-adjusted cut-offs in patients over 65 years.

Frequently asked questions

What is the FIB-4 index?

A non-invasive estimate of hepatic fibrosis using age, AST, ALT, and platelet count. It helps decide who needs further fibrosis assessment.

How is FIB-4 interpreted?

< 1.45 makes advanced fibrosis (F3–F4) unlikely; > 3.25 makes it likely; 1.45–3.25 is indeterminate and warrants elastography or biopsy.

In which diseases is FIB-4 used?

Originally HIV/HCV co-infection; now widely used in NAFLD/MASLD, chronic hepatitis B/C, and alcohol-related liver disease.

What are FIB-4 limitations?

Lower specificity in patients > 65 years (age-adjusted cut-offs are recommended) and unreliable with acute hepatitis or thrombocytopenia from other causes.

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