Cockcroft-Gault Creatinine Clearance

Estimate creatinine clearance using the Cockcroft-Gault formula. Output classified by KDIGO CKD stage.

For educational and clinical reference. Not a substitute for medical judgment.
Creatinine Clearance
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KDIGO Stage
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References

  1. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31-41.
  2. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int. 2024;105(4S):S117-S314.

What is Cockcroft-Gault Creatinine Clearance?

The Cockcroft-Gault formula estimates creatinine clearance (CrCl) — an approximation of glomerular filtration rate — from age, body weight, sex, and serum creatinine. Published by Cockcroft and Gault in 1976, the equation is CrCl (mL/min) = [(140 − age) × weight (kg)] / (72 × creatinine) × 0.85 if female. Although CKD-EPI is now preferred for CKD staging, Cockcroft-Gault remains the reference equation in the majority of FDA drug labels for renal dose adjustment, including for direct oral anticoagulants and many antimicrobials. Accuracy is reduced in obesity, low muscle mass, and extremes of age.

How to use

  1. Enter age, weight, serum creatinine, and sex.
  2. CrCl and KDIGO CKD stage update instantly.
  3. Use the copy button to copy results.

Frequently asked questions

What is the Cockcroft-Gault formula?

CrCl (mL/min) = ((140 − age) × weight in kg) / (72 × Cr in mg/dL). Multiply by 0.85 for females.

When should I use Cockcroft-Gault vs CKD-EPI?

Cockcroft-Gault is still recommended by the FDA for drug dosing in renal impairment. CKD-EPI is preferred for CKD staging.

Should I use actual or ideal body weight?

Use actual weight for underweight patients; consider ideal or adjusted weight in obesity to avoid overestimating clearance.

What units does this calculator use?

Weight in kg, creatinine in mg/dL, age in years. Output is mL/min.

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