Transferrin Saturation (TSAT) Calculator

Calculate transferrin saturation (TSAT) from serum iron and total iron-binding capacity (TIBC).

For educational and clinical reference. Not a substitute for medical judgment. See the medical disclaimer.
Transferrin Saturation
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Interpretation
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References

  1. Camaschella C. Iron-deficiency anemia. N Engl J Med. 2015;372(19):1832-1843.
  2. KDIGO Clinical Practice Guideline for Anemia in CKD. Kidney Int Suppl. 2012;2(4):279-335.

How to use

  1. Enter serum iron (µg/dL) and TIBC (µg/dL).
  2. TSAT updates instantly with iron-status interpretation.
  3. Same units must be used for both values.

Frequently asked questions

How is TSAT calculated?

TSAT (%) = (serum iron / TIBC) × 100.

What is normal TSAT?

Normal range is approximately 20–45%. TSAT < 20% suggests iron deficiency; TSAT > 45% suggests iron overload (e.g., hemochromatosis).

Why measure TSAT?

TSAT is part of the standard iron-studies panel and is more specific than ferritin alone, which is also an acute-phase reactant.

When is TSAT misleading?

TSAT is less reliable in acute illness or inflammation, where serum iron may be transiently decreased.

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