Sepsis-Induced Coagulopathy (SIC) Score Calculator

ISTH Sepsis-Induced Coagulopathy (SIC) score for early sepsis-associated coagulopathy (0–6).

For educational and clinical reference. Not a substitute for medical judgment. See the medical disclaimer.
Score
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Interpretation
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References

  1. Iba T, Nisio MD, Levy JH, et al. New criteria for sepsis-induced coagulopathy (SIC) following the revised sepsis definition: a retrospective analysis. BMJ Open. 2017;7(9):e017046.

How to use

  1. Select the INR band, platelet band, and capped SOFA category.
  2. The total SIC score (0–6) and interpretation update instantly.
  3. A total ≥ 4 diagnoses sepsis-induced coagulopathy.

Frequently asked questions

What is the SIC score?

The ISTH Sepsis-Induced Coagulopathy score uses PT-INR, platelet count, and a capped SOFA subscore to identify early sepsis-associated coagulopathy preceding overt DIC.

What SIC score makes the diagnosis?

A total score ≥ 4 (with the platelet and PT items contributing) defines SIC under the ISTH 2017 criteria.

How is the SOFA component scored?

Sum the respiratory, cardiovascular, hepatic, and renal SOFA subscores; the SIC item is 0 if that sum is 0, 1 if 1, and 2 if ≥ 2 (capped at 2 points).

SIC vs overt DIC?

SIC detects coagulopathy earlier than the ISTH overt-DIC score; many SIC-positive patients progress to DIC if untreated.

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