R-ISS Calculator (Multiple Myeloma)

Revised International Staging System (R-ISS) for multiple myeloma prognosis (Stage I–III).

For educational and clinical reference. Not a substitute for medical judgment. See the medical disclaimer.
R-ISS stage
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Prognosis
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References

  1. Palumbo A, Avet-Loiseau H, Oliva S, et al. Revised International Staging System for multiple myeloma. J Clin Oncol. 2015;33(26):2863-2869.

How to use

  1. Select the ISS stage, then mark high-risk cytogenetics and elevated LDH if present.
  2. The R-ISS stage and prognosis update instantly.
  3. Use for prognostic counselling and trial stratification.

Frequently asked questions

What is the R-ISS?

The Revised International Staging System for multiple myeloma combines the ISS stage (albumin, β2-microglobulin), high-risk FISH cytogenetics, and serum LDH into three prognostic stages.

How are the R-ISS stages defined?

Stage I = ISS I + standard-risk cytogenetics + normal LDH; Stage III = ISS III + (high-risk cytogenetics or high LDH); Stage II = all other combinations.

What is high-risk cytogenetics?

Presence of del(17p), t(4;14), or t(14;16) by interphase FISH.

What is the ISS stage based on?

ISS I: β2-microglobulin < 3.5 mg/L and albumin ≥ 3.5 g/dL; ISS III: β2-microglobulin ≥ 5.5 mg/L; ISS II: neither I nor III.

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