MASCC Risk Index Calculator

MASCC risk index for identifying low-risk febrile neutropenia (max 26).

For educational and clinical reference. Not a substitute for medical judgment. See the medical disclaimer.

Burden of febrile neutropenia (clinical illness severity)

No hypotension (systolic BP > 90 mmHg)

No chronic obstructive pulmonary disease

Solid tumor, or hematologic malignancy with no previous fungal infection

No dehydration requiring parenteral fluids

Outpatient status at onset of fever

Age < 60 years

Score

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Interpretation

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References

Klastersky J, Paesmans M, Rubenstein EB, et al. The MASCC risk-index: a multinational scoring system for identifying low-risk febrile neutropenic cancer patients. J Clin Oncol. 2000;18(16):3038-3051.

How to use

Select the burden-of-illness category and each other criterion.
The total MASCC score (max 26) and risk band update instantly.
A score ≥ 21 identifies low-risk patients who may be eligible for outpatient therapy.

Frequently asked questions

What is the MASCC risk index?

The Multinational Association for Supportive Care in Cancer index identifies low-risk febrile neutropenia patients who may be candidates for oral or outpatient antibiotic therapy.

What MASCC score is low risk?

A score ≥ 21 (maximum 26) predicts low risk of serious complications; < 21 is high risk and warrants inpatient intravenous management.

Note about the burden-of-illness item

Only one burden category is scored — “no/mild symptoms” (5) and “moderate symptoms” (3) are mutually exclusive options, not additive.

Does a low-risk MASCC mean home treatment is safe?

It identifies candidates, but outpatient management also requires clinical stability, reliable follow-up, access to care, and absence of profound prolonged neutropenia.

Last updated June 28, 2026